Transmembrane Interactions Are Needed for KAI1/CD82-Mediated Suppression of Cancer Invasion and Metastasis

In transmembrane (TM) domains, tetraspanin KAI1/CD82 contains an Asn, a Gln, and a Glu polar residue. A mutation of all three polar residues largely disrupts the migration-, invasion-, and metastasis-suppressive activities of KAI1/CD82. Notably, KAI1/CD82 inhibits the formation of microprotrusions a...

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Detalhes bibliográficos
Main Authors: Bari, Rafijul, Zhang, Yanhui H., Zhang, Feng, Wang, Nick X., Stipp, Christopher S., Zheng, Jie J., Zhang, Xin A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630572/
https://ncbi.nlm.nih.gov/pubmed/19116362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080685
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