Activin-Like Kinase 5 (ALK5) Mediates Abnormal Proliferation of Vascular Smooth Muscle Cells from Patients with Familial Pulmonary Arterial Hypertension and Is Involved in the Progression of Experimental Pulmonary Arterial Hypertension Induced by Monocrotaline

Mutations in the gene for the transforming growth factor (TGF)-β superfamily receptor, bone morphogenetic protein receptor II, underlie heritable forms of pulmonary arterial hypertension (PAH). Aberrant signaling via TGF-β receptor I/activin receptor-like kinase 5 may be important for both the devel...

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Detalhes bibliográficos
Main Authors: Thomas, Matthew, Docx, Cerys, Holmes, Alan M., Beach, Sarah, Duggan, Nicholas, England, Karen, Leblanc, Catherine, Lebret, Clemence, Schindler, Francis, Raza, Farheen, Walker, Christoph, Crosby, Alexi, Davies, Rachel J., Morrell, Nicholas W., Budd, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630548/
https://ncbi.nlm.nih.gov/pubmed/19116361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080565
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