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Loss of PKCθ, Bcl10, or Malt1 selectively impairs proliferation and NF-κB activation in the CD4(+) T cell subset
The cytosolic proteins PKCθ, Bcl10, and Malt1 play critical roles in T cell receptor (TCR) signaling to the transcription factor nuclear factor κB (NF-κB). Our data confirm that CD4(+) T cells from PKCθ, Bcl10 and Malt1 knock-out mice show severe impairment of proliferation in response to TCR stimul...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2630173/ https://ncbi.nlm.nih.gov/pubmed/18941215 |
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