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Adaptive Mutations in the JC Virus Protein Capsid Are Associated with Progressive Multifocal Leukoencephalopathy (PML)

PML is a progressive and mostly fatal demyelinating disease caused by JC virus infection and destruction of infected oligodendrocytes in multiple brain foci of susceptible individuals. While JC virus is highly prevalent in the human population, PML is a rare disease that exclusively afflicts only a...

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Библиографические подробности
Главные авторы: Sunyaev, Shamil R., Lugovskoy, Alexey, Simon, Kenneth, Gorelik, Leonid
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2009
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629573/
https://ncbi.nlm.nih.gov/pubmed/19197354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000368
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