Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Metastatic Melanoma

PURPOSE: Activation of the mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol 3-kinase/AKT pathway seems to be critical for melanoma proliferation. Components of these pathways are client proteins of heat-shock protein 90 (hsp90), suggesting that inhibition of hsp90 could h...

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Hlavní autoři: Solit, David B., Osman, Iman, Polsky, David, Panageas, Katherine S., Daud, Adil, Goydos, James S., Teitcher, Jerrold, Wolchok, Jedd D., Germino, F. Joseph, Krown, Susan E., Coit, Daniel, Rosen, Neal, Chapman, Paul B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629404/
https://ncbi.nlm.nih.gov/pubmed/19088048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-1002
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