Incompatibility with Formin Cdc12p Prevents Human Profilin from Substituting for Fission Yeast Profilin: INSIGHTS FROM CRYSTAL STRUCTURES OF FISSION YEAST PROFILIN

Expression of human profilin-I does not complement the temperature-sensitive cdc3-124 mutation of the single profilin gene in fission yeast Schizosaccharomyces pombe, resulting in death from cytokinesis defects. Human profilin-I and S. pombe profilin have similar affinities for actin monomers, the F...

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Bibliografiske detaljer
Main Authors: Ezezika, Obidimma C., Younger, Noah S., Lu, Jia, Kaiser, Donald A., Corbin, Zachary A., Nolen, Bradley J., Kovar, David R., Pollard, Thomas D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Molecular Basis of Cell and Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629104/
https://ncbi.nlm.nih.gov/pubmed/19028693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807073200
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