Glycosylphosphatidylinositol-anchored Protein Deficiency Confers Resistance to Apoptosis in PNH

OBJECTIVE: Investigate the contribution of PIG-A mutations to clonal expansion in paroxysmal nocturnal hemoglobinuria (PNH). METHODS: Primary CD34(+) hematopoietic progenitors from PNH patients were assayed for annexin V positivity by flow cytometry in a cell-mediated killing assay using autologous...

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Detalhes bibliográficos
Main Authors: Savage, William J., Barber, James P., Mukhina, Galina L., Hu, Rong, Chen, Guibin, Matsui, William, Thoburn, Chris, Hess, Allan D., Cheng, Linzhao, Jones, Richard J., Brodsky, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628761/
https://ncbi.nlm.nih.gov/pubmed/19013003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2008.09.002
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