Open-Label, Dose Escalation Phase I Study in Healthy Volunteers to Evaluate the Safety and Pharmacokinetics of a Human Monoclonal Antibody to Clostridium difficile Toxin A

BACKGROUND: Recent data suggest that Clostridium difficile-associated diarrhea is becoming more severe and difficult to treat. Antibody responses to C. difficile toxin A are protective against symptomatic disease and recurrence. We examined the safety and pharmacokinetics (pk) of a novel neutralizin...

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Detalhes bibliográficos
Main Authors: Taylor, Claribel P., Tummala, Sanjeev, Molrine, Deborah, Davidson, Lisa, Farrell, Richard J., Lembo, Anthony, Hibberd, Patricia L., Lowy, Israel, Kelly, Ciaran P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628753/
https://ncbi.nlm.nih.gov/pubmed/18502001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2008.04.042
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