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Naloxone's Pentapeptide Binding Site on Filamin A Blocks Mu Opioid Receptor–Gs Coupling and CREB Activation of Acute Morphine

Chronic morphine causes the mu opioid receptor (MOR) to switch its coupling from Gi/o to Gs, resulting in excitatory signaling via both Gαs and its Gβγ dimer. Ultra-low-dose naloxone (NLX) prevents this switch and attenuates opioid tolerance and dependence. This protective effect is mediated via a h...

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Detalhes bibliográficos
Main Authors: Wang, Hoau-Yan, Burns, Lindsay H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628740/
https://ncbi.nlm.nih.gov/pubmed/19172190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004282
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