Somatostatin Secreted by Islet δ-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

OBJECTIVE— Somatostatin (SST) is secreted by islet δ-cells and by extraislet neuroendocrine cells. SST receptors have been identified on α- and β-cells, and exogenous SST inhibits insulin and glucagon secretion, consistent with a role for SST in regulating α- and β-cell function. However, the specif...

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Autori principali: Hauge-Evans, Astrid C., King, Aileen J., Carmignac, Danielle, Richardson, Carolyn C., Robinson, Iain C.A.F., Low, Malcolm J., Christie, Michael R., Persaud, Shanta J., Jones, Peter M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2009
Soggetti:
Islet Studies
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628614/
https://ncbi.nlm.nih.gov/pubmed/18984743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0792
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