Overexpression of SIRT1 Protects Pancreatic β-Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor-κB Signaling Pathway

OBJECTIVE—SIRT1, a class III histone/protein deacetylase, is known to interfere with the nuclear factor-κB (NF-κB) signaling pathway and thereby has an anti-inflammatory function. Because of the central role of NF-κB in cytokine-mediated pancreatic β-cell damage, we postulated that SIRT1 might work...

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Main Authors: Lee, Ji-Hyun, Song, Mi-Young, Song, Eun-Kyung, Kim, Eun-Kyung, Moon, Woo Sung, Han, Myung-Kwan, Park, Jin-Woo, Kwon, Kang-Beom, Park, Byung-Hyun
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2009
Assuntos:
Metabolism
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628607/
https://ncbi.nlm.nih.gov/pubmed/19008341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1795
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