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Overexpression of SIRT1 Protects Pancreatic β-Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor-κB Signaling Pathway
OBJECTIVE—SIRT1, a class III histone/protein deacetylase, is known to interfere with the nuclear factor-κB (NF-κB) signaling pathway and thereby has an anti-inflammatory function. Because of the central role of NF-κB in cytokine-mediated pancreatic β-cell damage, we postulated that SIRT1 might work...
Wedi'i Gadw mewn:
Prif Awduron: | , , , , , , , , |
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Fformat: | Artigo |
Iaith: | Inglês |
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American Diabetes Association
2009
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Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2628607/ https://ncbi.nlm.nih.gov/pubmed/19008341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1795 |
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