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Rapid, deletional peripheral CD8 T cell tolerance induced by allogeneic bone marrow: role of donor class II MHC and B cells

Mixed chimerism and donor-specific tolerance are achieved in mice receiving 3 Gy total body irradiation and anti-CD154 monoclonal antibody (mAb) followed by allogeneic bone marrow transplantation (BMT). In this model, recipient CD4 cells are critically important for CD8 tolerance. To evaluate the ro...

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Detalhes bibliográficos
Main Authors: Fehr, Thomas, Wang, Sophia, Haspot, Fabienne, Kurtz, Josef, Blaha, Peter, Hogan, Timothy, Chittenden, Meredith, Wekerle, Thomas, Sykes, Megan
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628539/
https://ncbi.nlm.nih.gov/pubmed/18768896
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