Physiological consequences of the P2328S mutation in the ryanodine receptor (RyR2) gene in genetically modified murine hearts

AIM: To explore the physiological consequences of the ryanodine receptor (RyR2)-P2328S mutation associated with catecholaminergic polymorphic ventricular tachycardia (CPVT). METHODS: We generated heterozygotic (RyR2(p/s)) and homozygotic (RyR2(s/s)) transgenic mice and studied Ca(2+) signals from re...

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Bibliographische Detailangaben
Hauptverfasser: Goddard, C A, Ghais, N S, Zhang, Y, Williams, A J, Colledge, W H, Grace, A A, Huang, C L-H
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2008
Schlagworte:
Cardiovascular
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628439/
https://ncbi.nlm.nih.gov/pubmed/18419777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1748-1716.2008.01865.x
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