The inhibition of assembly of HIV-1 virus-like particles by 3-O-(3',3'-dimethylsuccinyl) betulinic acid (DSB) is counteracted by Vif and requires its Zinc-binding domain

BACKGROUND: DSB, the 3-O-(3',3'dimethylsuccinyl) derivative of betulinic acid, blocks the last step of protease-mediated processing of HIV-1 Gag precursor (Pr55Gag), which leads to immature, noninfectious virions. When administered to Pr55Gag-expressing insect cells (Sf9), DSB inhibits the...

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Detalhes bibliográficos
Main Authors: DaFonseca, Sandrina, Coric, Pascale, Gay, Bernard, Hong, Saw See, Bouaziz, Serge, Boulanger, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628355/
https://ncbi.nlm.nih.gov/pubmed/19105849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-5-162
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