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P-gp Inhibition Potential in Cell-Based Models: Which “Calculation” Method is the Most Accurate?

The objective was to directly compare the four different “calculation” methods of assessing P-gp inhibition potential using experimental data obtained from ~60 structurally diverse internal research and marketed compounds. Bidirectional studies for digoxin (probe for P-gp substrate) were performed w...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Balimane, Praveen V., Marino, Anthony, Chong, Saeho
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer US 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628205/
https://ncbi.nlm.nih.gov/pubmed/19082742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-008-9068-x
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