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P-gp Inhibition Potential in Cell-Based Models: Which “Calculation” Method is the Most Accurate?
The objective was to directly compare the four different “calculation” methods of assessing P-gp inhibition potential using experimental data obtained from ~60 structurally diverse internal research and marketed compounds. Bidirectional studies for digoxin (probe for P-gp substrate) were performed w...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2628205/ https://ncbi.nlm.nih.gov/pubmed/19082742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-008-9068-x |
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