Graded Smad2/3 Activation Is Converted Directly into Levels of Target Gene Expression in Embryonic Stem Cells

The Transforming Growth Factor (TGF) β signalling family includes morphogens, such as Nodal and Activin, with important functions in vertebrate development. The concentration of the morphogen is critical for fate decisions in the responding cells. Smad2 and Smad3 are effectors of the Nodal/Activin b...

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Bibliographic Details
Main Authors: Guzman-Ayala, Marcela, Lee, Kian Leong, Mavrakis, Konstantinos J., Goggolidou, Paraskevi, Norris, Dominic P., Episkopou, Vasso
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2627943/
https://ncbi.nlm.nih.gov/pubmed/19172185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004268
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