Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia

BACKGROUND: The combination of artesunate and mefloquine was introduced as the national first-line treatment for Plasmodium falciparum malaria in Cambodia in 2000. However, recent clinical trials performed at the Thai-Cambodian border have pointed to the declining efficacy of both artesunate-mefloqu...

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Huvudupphovsmän: Lim, Pharath, Alker, Alisa P, Khim, Nimol, Shah, Naman K, Incardona, Sandra, Doung, Socheat, Yi, Poravuth, Bouth, Denis Mey, Bouchier, Christiane, Puijalon, Odile Mercereau, Meshnick, Steven R, Wongsrichanalai, Chansuda, Fandeur, Thierry, Le Bras, Jacques, Ringwald, Pascal, Ariey, Frédéric
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2009
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2627910/
https://ncbi.nlm.nih.gov/pubmed/19138391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-8-11
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