Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia

Loss-of-function mutations in telomerase complex genes can cause bone marrow failure, dyskeratosis congenita, and acquired aplastic anemia, both diseases that predispose to acute myeloid leukemia. Loss of telomerase function produces short telomeres, potentially resulting in chromosome recombination...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Calado, Rodrigo T., Regal, Joshua A., Hills, Mark, Yewdell, William T., Dalmazzo, Leandro F., Zago, Marco A., Lansdorp, Peter M., Hogge, Donna, Chanock, Stephen J., Estey, Elihu H., Falcão, Roberto P., Young, Neal S.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2009
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2627806/
https://ncbi.nlm.nih.gov/pubmed/19147845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807057106
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires