Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-γ signaling for glutamate release via a glutamate transporter

An increase in glucocorticoid levels and down-regulation of BDNF (brain-derived neurotrophic factor) are supposed to be involved in the pathophysiology of depressive disorders. However, possible crosstalk between glucocorticoid- and BDNF-mediated neuronal functions in the CNS has not been elucidated...

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Autori principali: Numakawa, Tadahiro, Kumamaru, Emi, Adachi, Naoki, Yagasaki, Yuki, Izumi, Aiko, Kunugi, Hiroshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626757/
https://ncbi.nlm.nih.gov/pubmed/19126684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800888106
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