Human Immunodeficiency Virus Type 1 hnRNP A/B-Dependent Exonic Splicing Silencer ESSV Antagonizes Binding of U2AF65 to Viral Polypyrimidine Tracts

Human immunodeficiency virus type 1 (HIV-1) exonic splicing silencers (ESSs) inhibit production of certain spliced viral RNAs by repressing alternative splicing of the viral precursor RNA. Several HIV-1 ESSs interfere with spliceosome assembly by binding cellular hnRNP A/B proteins. Here, we have fu...

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Auteurs principaux: Domsic, Jeffrey K., Wang, Yibin, Mayeda, Akila, Krainer, Adrian R., Stoltzfus, C. Martin
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2003
Sujets:
Gene Expression
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC262674/
https://ncbi.nlm.nih.gov/pubmed/14612416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.23.8762-8772.2003
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