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Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus

The M2 protein of the influenza A virus is activated by low endosomal pH and performs the essential function of proton transfer into the viral interior. The resulting decrease in pH within the virion is essential for the uncoating and further replication of the viral genetic material. The x-ray crys...

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Main Authors: Khurana, Ekta, Peraro, Matteo Dal, DeVane, Russell, Vemparala, Satyavani, DeGrado, William F., Klein, Michael L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626606/
https://ncbi.nlm.nih.gov/pubmed/19144924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811720106
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