Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus

The M2 protein of the influenza A virus is activated by low endosomal pH and performs the essential function of proton transfer into the viral interior. The resulting decrease in pH within the virion is essential for the uncoating and further replication of the viral genetic material. The x-ray crys...

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Bibliographic Details
Main Authors: Khurana, Ekta, Peraro, Matteo Dal, DeVane, Russell, Vemparala, Satyavani, DeGrado, William F., Klein, Michael L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626606/
https://ncbi.nlm.nih.gov/pubmed/19144924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811720106
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