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mTOR-Dependent Regulation of Ribosomal Gene Transcription Requires S6K1 and Is Mediated by Phosphorylation of the Carboxy-Terminal Activation Domain of the Nucleolar Transcription Factor UBF†

Mammalian target of rapamycin (mTOR) is a key regulator of cell growth acting via two independent targets, ribosomal protein S6 kinase 1 (S6K1) and 4EBP1. While each is known to regulate translational efficiency, the mechanism by which they control cell growth remains unclear. In addition to increas...

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Guardat en:
Publicat a:Mol Cell Biol
Autors principals: Hannan, Katherine M., Brandenburger, Yves, Jenkins, Anna, Sharkey, Kerith, Cavanaugh, Alice, Rothblum, Lawrence, Moss, Tom, Poortinga, Gretchen, McArthur, Grant A., Pearson, Richard B., Hannan, Ross D.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2003
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC262650/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14612424/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.23.8862-8877.2003
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