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Quantitative Analysis of DNA Interstrand Cross-links and Monoadducts Formed in Human Cells Induced by Psoralens and UVA Irradiation

Upon exposure to UVA light, psoralens can induce DNA interstrand cross-links (ICLs), which can block DNA replication and transcription. Among the psoralen derivatives, 8-methoxypsoralen (8-MOP) is conventionally applied for psoriasis therapy, and amotosalen S59 is used to inactivate bacterial and vi...

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Bibliografische gegevens
Hoofdauteurs: Lai, Congfang, Cao, Huachuan, Hearst, John E., Corash, Laurence, Luo, Hai, Wang, Yinsheng
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626160/
https://ncbi.nlm.nih.gov/pubmed/18947205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac801520m
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