Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons

Prolonged light exposure is a determinant factor in inducing neurodegeneration of photoreceptors by apoptosis. Yet, the molecular bases of the pathways and components triggering this cell death event are elusive. Here, we reveal a prominent age-dependent increase in the susceptibility of photorecept...

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Hlavní autoři: Cho, Kyoung-in, Yi, Haiqing, Yeh, Andrew, Tserentsoodol, Nomingerel, Cuadrado, Lori, Searle, Kelly, Hao, Ying, Ferreira, Paulo A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626153/
https://ncbi.nlm.nih.gov/pubmed/18949001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2008.153
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