Interactions between Human Cytomegalovirus IE1-72 and Cellular p107: Functional Domains and Mechanisms of Up-Regulation of Cyclin E/cdk2 Kinase Activity

Previous work has demonstrated that the human cytomegalovirus IE1-72 protein is able to bind to the N terminus of p107, and IE1-72 alone is sufficient for alleviation of p107-mediated cell growth suppression. However, the mechanism of this alleviation is unclear. Here, we show that IE1-72 can allevi...

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Autores principales: Zhang, Zhigang, Huong, Shu-Mei, Wang, Xin, Huang, David Y., Huang, Eng-Shang
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC262583/
https://ncbi.nlm.nih.gov/pubmed/14610188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.23.12660-12670.2003
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