The TEL/platelet-derived growth factor β receptor (PDGFβR) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGFβR kinase-dependent signaling pathways

The TEL/PDGFβR fusion protein is the product of the t(5;12) translocation in patients with chronic myelomonocytic leukemia. The TEL/PDGFβR is an unusual fusion of a putative transcription factor, TEL, to a receptor tyrosine kinase. The translocation fuses the amino terminus of TEL, containing the he...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Carroll, Martin, Tomasson, Michael H., Barker, George F., Golub, Todd R., Gilliland, D. Gary
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1996
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26224/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8962143/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.25.14845
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