In Vivo Effect of Mutations at the PRPP Binding Site of the Bacillus subtilis Purine Repressor

The Bacillus subtilis PurR mediates adenine repression and guanosine induction of purA. PRPP inhibits binding of PurR to DNA in vitro. Mutations in the PRPP binding motif of PurR caused strong repression regardless of purine exclusions or additions, establishing the role of PRPP as regulator of PurR...

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Bibliographic Details
Main Authors: Rappu, Pekka, Pullinen, Terhi, Mäntsälä, Pekka
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC262106/
https://ncbi.nlm.nih.gov/pubmed/14594850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.185.22.6728-6731.2003
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