Quantitative Proteomics Analysis of Macrophage Rafts Reveals Compartmentalized Activation of the Proteasome and of Proteasome-mediated ERK Activation in Response to Lipopolysaccharide

Lipopolysaccharide (LPS), a glycolipid component of the outer membrane of Gram-negative bacteria, is a potent initiator of the innate immune response of the macrophage. LPS triggers downstream signaling by selectively recruiting and activating proteins in cholesterol-rich membrane microdomains calle...

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Bibliographic Details
Main Authors: Dhungana, Suraj, Merrick, B. Alex, Tomer, Kenneth B., Fessler, Michael B.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2621002/
https://ncbi.nlm.nih.gov/pubmed/18815123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M800286-MCP200
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