Imatinib Suppresses Cryoglobulinemia and Secondary Membranoproliferative Glomerulonephritis

Imatinib is a receptor tyrosine kinase inhibitor that blocks the activity of c-Abl, c-Kit, and PDGF receptors. We tested the protective effects of imatinib in thymic stromal lymphopoietin transgenic mice, a model of cryoglobulinemia and associated membranoproliferative glomerulonephritis (MPGN), in...

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Autori principali: Iyoda, Masayuki, Hudkins, Kelly L., Becker-Herman, Shirly, Wietecha, Tomasz A., Banas, Miriam C., Guo, Shunhua, Meyer-Bahlburg, Almut, Kowalewska, Jolanta, Liu, Gang, Ziegler, Steven F., Rawlings, David J., Alpers, Charles E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2009
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615727/
https://ncbi.nlm.nih.gov/pubmed/19020005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008010036
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