Comparative Analysis of Paired- and Homeodomain-specific Roles in PAX3-FKHR Oncogenesis

The alveolar rhabdomyosarcoma-associated t(2;13) chromosomal translocation produces an oncogenic fusion transcription factor PAX3-FKHR that combines the N-terminal DNA binding domains (paired domain and homeodomain) of PAX3 with the C-terminal activation domain of FKHR. In the context of PAX3-FKHR,...

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Bibliographic Details
Main Authors: Zhang, Youbin, Schwartz, Joel, Wang, Chiayeng
Format: Artigo
Language:Inglês
Published: e-Century Publishing Corporation 2008
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615594/
https://ncbi.nlm.nih.gov/pubmed/19158934
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