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Correlation of bilayer membrane cation transport and biological activity in alkyl-substituted lariat ethers

Dialkyldiaza-18-crown-6 lariat ethers having twin n-octyl, n-decyl, n-dodecyl, n-tetradecyl, n-hexadecyl, 1-oxodecyl and 1-oxododecyl side arms were prepared and studied. Cation transport in liposomes mediated by these compounds showed discontinuous activity that correlated with toxicity to the bact...

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Detalhes bibliográficos
Main Authors: Leevy, W. Matthew, Weber, Michelle E., Gokel, Michael R., Hughes-Strange, George B., Daranciang, David D., Ferdani, Riccardo, Gokel, George W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615582/
https://ncbi.nlm.nih.gov/pubmed/15858645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b418194h
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