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Endothelin-1 Inhibits Thick Ascending Limb Transport via Akt-stimulated Nitric Oxide Production

Endothelin-1 inhibits sodium reabsorption in the thick ascending limb (THAL) via stimulation of nitric oxide (NO) production. The mechanism whereby endothelin-1 stimulates THAL NO is unknown. We hypothesized that endothelin-1 stimulates THAL NO production by activating phosphatidylinositol 3-kinase...

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Autors principals: Herrera, Marcela, Hong, Nancy J., Ortiz, Pablo A., Garvin, Jeffrey L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615526/
https://ncbi.nlm.nih.gov/pubmed/19033447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804322200
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