Disruption of Protein Kinase A Interaction with A-kinase-anchoring Proteins in the Heart in Vivo: EFFECTS ON CARDIAC CONTRACTILITY, PROTEIN KINASE A PHOSPHORYLATION, AND TROPONIN I PROTEOLYSIS

Protein kinase A (PKA)-dependent phosphorylation is regulated by targeting of PKA to its substrate as a result of binding of regulatory subunit, R, to A-kinase-anchoring proteins (AKAPs). We investigated the effects of disrupting PKA targeting to AKAPs in the heart by expressing the 24-amino acid re...

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Detalhes bibliográficos
Main Authors: McConnell, Bradley K., Popovic, Zoran, Mal, Niladri, Lee, Kwangdeok, Bautista, James, Forudi, Farhad, Schwartzman, Raul, Jin, J.-P., Penn, Marc, Bond, Meredith
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615525/
https://ncbi.nlm.nih.gov/pubmed/18945669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806321200
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