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CD4 cell-secreted, posttranslationally modified cytokine GIF suppresses Th2 responses by inhibiting the initiation of IL-4 production

T helper 2 (Th2) cells are critical to the induction of IgE antibody and allergic inflammation, but how the pathological pathways are controlled in nonallergic individuals remains unclear. Here we report that glycosylation-inhibiting factor (GIF) suppresses Th2 effector generation. GIF is a cytokine...

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Sonraí Bibleagrafaíochta
Main Authors: Kim-Saijo, Misa, Janssen, Edith M., Sugie, Katsuji
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614773/
https://ncbi.nlm.nih.gov/pubmed/19036925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810035105
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