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In vitro unfolding of yeast multicopper oxidase Fet3p variants reveals unique role of each metal site

Fet3p from Saccharomyces cerevisiae is a multicopper oxidase (MCO) that contains 3 cupredoxin-like β-barrel domains and 4 copper ions located in 3 distinct metal sites (T1 in domain 3, T2, and the binuclear T3 at the interface between domains 1 and 3). To better understand how protein structure and...

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Detalhes bibliográficos
Main Authors: Sedlák, Erik, Ziegler, Lynn, Kosman, Daniel J., Wittung-Stafshede, Pernilla
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614749/
https://ncbi.nlm.nih.gov/pubmed/19033465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806431105
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