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Tumor-derived extracellular mutations of PTPRT/PTPρ are deficient in cell adhesion

Receptor protein tyrosine phosphatase T (PTPRT/PTPρ) is frequently mutated in human cancers including colon, lung, gastric and skin cancers. More than half of the identified tumor-derived mutations are located in the extracellular part of PTPρ. However, the functional significance of those extracell...

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Detalhes bibliográficos
Main Authors: Yu, Jianshi, Becka, Scott, Zhang, Peng, Zhang, Xiaodong, Brady-Kalnay, Susann M., Wang, Zhenghe
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614372/
https://ncbi.nlm.nih.gov/pubmed/18644975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-07-2123
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