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Disproportional effects of Igf2 knockout on placental morphology and diffusional exchange characteristics in the mouse

Both complete knockout of the Igf2 gene (Igf2null(+/−)) and knockout of its placental specific transcript alone (Igf2P0(+/−)) lead to fetal growth restriction in mice. However, in the Igf2null(+/−) this growth restriction occurs concurrently in gestation with placental growth restriction, whereas, p...

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Autores principales: Coan, P M, Fowden, A L, Constancia, M, Ferguson-Smith, A C, Burton, G J, Sibley, C P
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614051/
https://ncbi.nlm.nih.gov/pubmed/18755750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.157313
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