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A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis
We identified a novel inhibitor of growth family member 2 (ING2) isoform, ING2b, which shares exon 2 with ING2a, but lacks the N-terminal p53 binding region. Contrary to ING2a, ING2b's promoter has no p53 binding sites. Consistently, activation of p53 led to suppression of ING2a, leaving ING2b...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2613974/ https://ncbi.nlm.nih.gov/pubmed/18951897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2008.10.024 |
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