Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic Resistance

Penicillin-binding protein 2 (PBP2) from N. gonorrhoeae is the major molecular target for β-lactam antibiotics used to treat gonococcal infections. PBP2 from penicillin-resistant strains of N. gonorrhoeae harbors an aspartate insertion after position 345 (Asp-345a) and 4-8 additional mutations, but...

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Detalhes bibliográficos
Main Authors: Powell, Ailsa J., Tomberg, Joshua, Deacon, Ashley M., Nicholas, Robert A., Davies, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613624/
https://ncbi.nlm.nih.gov/pubmed/18986991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805761200
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