Synthesis, Modeling, and Biological Evaluation of Analogues of the Semisynthetic Brevetoxin Antagonist β-Naphthoyl-Brevetoxin

Brevetoxins are neurotoxic compounds produced by the dinoflagellate Karenia brevis. Extensive blooms induce neurotoxic shellfish poisoning (NSP) and asthma-like symptoms in humans. β-naphthoyl-brevetoxin, the first semisynthetic brevetoxin antagonist, has been defined as the lead compound in the inv...

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Bibliographic Details
Main Authors: Michelliza, Sophie, Abraham, William M., Jacocks, Henry M., Schuster, Thomas, Baden, Daniel G.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613567/
https://ncbi.nlm.nih.gov/pubmed/18000915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200700317
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