Deletion of the von Hippel–Lindau gene in pancreatic β cells impairs glucose homeostasis in mice

Defective insulin secretion in response to glucose is an important component of the β cell dysfunction seen in type 2 diabetes. As mitochondrial oxidative phosphorylation plays a key role in glucose-stimulated insulin secretion (GSIS), oxygen-sensing pathways may modulate insulin release. The von Hi...

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Autores principales: Cantley, James, Selman, Colin, Shukla, Deepa, Abramov, Andrey Y., Forstreuter, Frauke, Esteban, Miguel A., Claret, Marc, Lingard, Steven J., Clements, Melanie, Harten, Sarah K., Asare-Anane, Henry, Batterham, Rachel L., Herrera, Pedro L., Persaud, Shanta J., Duchen, Michael R., Maxwell, Patrick H., Withers, Dominic J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2008
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613475/
https://ncbi.nlm.nih.gov/pubmed/19065050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26934
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