The PmrA/PmrB Two-Component System of Legionella pneumophila Is a Global Regulator Required for Intracellular Replication within Macrophages and Protozoa

To examine the role of the PmrA/PmrB two-component system (TCS) of Legionella pneumophila in global gene regulation and in intracellular infection, we constructed pmrA and pmrB isogenic mutants by allelic exchange. Genome-wide microarray gene expression analyses of the pmrA and pmrB mutants at both...

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Detalhes bibliográficos
Main Authors: Al-Khodor, Souhaila, Kalachikov, Sergey, Morozova, Irina, Price, Christopher T., Abu Kwaik, Yousef
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Bacterial Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612241/
https://ncbi.nlm.nih.gov/pubmed/18936184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01081-08
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