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APIGENIN, A DIETARY FLAVONOID, SENSITIZES HUMAN T CELLS FOR ACTIVATION-INDUCED CELL DEATH BY INHIBITING PKB/Akt AND NF-κB ACTIVATION PATHWAY

Resistance of T cells to activation induced cell death (AICD) is associated with autoimmunity and lymphoproliferation. We found that apigenin (4′,5,7-Trihydroxyflavone), a nonmutagenic dietary flavonoid, augmented both extrinsic and intrinsic pathways of apoptosis in recurrently activated, but not i...

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Библиографические подробности
Главные авторы: Xu, Luting, Zhang, Li, Bertucci, Anne M., Pope, Richard M., Datta, Syamal K.
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610846/
https://ncbi.nlm.nih.gov/pubmed/18812189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.imlet.2008.08.004
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