Inhibition of Dipeptidyl Peptidase-4 by Vildagliptin During Glucagon-Like Peptide 1 Infusion Increases Liver Glucose Uptake in the Conscious Dog

OBJECTIVE—This study investigated the acute effects of treatment with vildagliptin on dipeptidyl peptidase-4 (DPP-4) activity, glucagon-like peptide 1 (GLP-1) concentration, pancreatic hormone levels, and glucose metabolism. The primary aims were to determine the effects of DPP-4 inhibition on GLP-1...

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Autors principals: Edgerton, Dale S., Johnson, Kathryn M.S., Neal, Doss W., Scott, Melanie, Hobbs, Charles H., Zhang, Xia, Duttaroy, Alokesh, Cherrington, Alan D.
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2009
Matèries:
Pharmacology & Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606880/
https://ncbi.nlm.nih.gov/pubmed/18840785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0515
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