Rho Kinase Inhibition by Fasudil Ameliorates Diabetes-Induced Microvascular Damage

OBJECTIVE—Leukocyte adhesion in retinal microvasuculature substantially contributes to diabetic retinopathy. Involvement of the Rho/Rho kinase (ROCK) pathway in diabetic microvasculopathy and therapeutic potential of fasudil, a selective ROCK inhibitor, are investigated. RESEARCH DESIGN AND METHODS—...

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Main Authors: Arita, Ryoichi, Hata, Yasuaki, Nakao, Shintaro, Kita, Takeshi, Miura, Muneki, Kawahara, Shuhei, Zandi, Souska, Almulki, Lama, Tayyari, Faryan, Shimokawa, Hiroaki, Hafezi-Moghadam, Ali, Ishibashi, Tatsuro
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Diabetes Association 2009
Ábhair:
Complications
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606876/
https://ncbi.nlm.nih.gov/pubmed/18840783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0762
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