Allopurinol and Nitric Oxide Activity in the Cerebral Circulation of Those With Diabetes: A randomized trial

OBJECTIVE—Type 2 diabetes increases risk of stroke, perhaps because of impaired cerebrovascular basal nitric oxide (NO) activity. We investigated whether this activity is improved by a 2-week course of the xanthine oxidase inhibitor allopurinol. RESEARCH DESIGN AND METHODS—We performed a randomized,...

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Detalhes bibliográficos
Main Authors: Dawson, Jesse, Quinn, Terry, Harrow, Craig, Lees, Kennedy R., Weir, Christopher J., Cleland, Stephen J., Walters, Matthew R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
Assuntos:
Pathophysiology/Complications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2606848/
https://ncbi.nlm.nih.gov/pubmed/18945924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc08-1179
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