Gla-rich Protein (GRP), A New Vitamin K-dependent Protein Identified from Sturgeon Cartilage and Highly Conserved in Vertebrates

We report the isolation of a novel vitamin K-dependent protein from the calcified cartilage of Adriatic sturgeon (Acipenser nacarii). This 10.2-kDa secreted protein contains 16 γ-carboxyglutamic acid (Gla) residues in its 74-residue sequence, the highest Gla percent of any known protein, and we have...

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Bibliographische Detailangaben
Hauptverfasser: Viegas, Carla S. B., Simes, Dina C., Laizé, Vincent, Williamson, Matthew K., Price, Paul A., Cancela, M. Leonor
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2605998/
https://ncbi.nlm.nih.gov/pubmed/18836183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802761200
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